I did it today and it worked. Here is the scenario:
Advil Congestion 10ct for $4.99
$1 off coupon in the Ad or there is also a Video Value coupon for $1 off
Pay $1.99 out of Pocket
Then you will get $4 in Up Rewards (1 $3 and 1 $1) and then submit for a $1 Single Check Rebate - Making this a $3 moneymaker!!